Identification of Mureidomycin Analogues and Functional Analysis of an N‐Acetyltransferase in Napsamycin Biosynthesis

ChemBioChem
2013.0

Abstract

Antibiotic abundance: Several new uridyl peptide antibiotics were identified from a heterologous producer strain containing the mureidomycin/napsamycin biosynthetic gene cluster by using HRMS and LC-ESI-MS/MS. Analysis of the new compounds and the corresponding gene cluster revealed NpsB, an N-acetyltransferase, to be responsible for acetylation of the uridyl peptide antibiotic. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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