Nerve Growth Factor-Potentiating Benzofuran Derivatives from the Medicinal Fungus Phellinus ribis

Journal of Natural Products
2012.0

Abstract

Four new benzofuran derivatives, ribisin A (1), ribisin B (2), ribisin C (3), and ribisin D (4), were isolated from the MeOH extract of the fruiting bodies of Phellinus ribis. Their structures including their absolute configurations were determined by NMR and CD exciton chirality methods. Compounds 1-4 were found to promote neurite outgrowth in NGF-mediated PC12 cells at concentrations ranging from 1 to 30 μM. The structure-activity relationships of these compounds are also discussed.

Knowledge Graph

Similar Paper

Nerve Growth Factor-Potentiating Benzofuran Derivatives from the Medicinal Fungus <i>Phellinus ribis</i>
Journal of Natural Products 2012.0
Structures, Biogenesis, and Biological Activities of Pyrano[4,3-<i>c</i>]isochromen-4-one Derivatives from the Fungus <i>Phellinus igniarius</i>
Journal of Natural Products 2007.0
Structures, Biogenesis, and Biological Activities of Pyrano[4,3-<i>c</i>]isochromen-4-one Derivatives from the Fungus <i>Phellinus igniarius</i>
Journal of Natural Products 2007.0
Phenolic compounds with NF-κB inhibitory effects from the fungus Phellinus baumii
Bioorganic &amp; Medicinal Chemistry Letters 2011.0
Scabronine M, a novel inhibitor of NGF-induced neurite outgrowth from PC12 cells from the fungus Sarcodon scabrosus
Bioorganic &amp; Medicinal Chemistry Letters 2012.0
Polychlorinated compounds with PPAR-γ agonistic effect from the medicinal fungus Phellinus ribis
Bioorganic &amp; Medicinal Chemistry Letters 2008.0
Phelligridins C−F:  Cytotoxic Pyrano[4,3-<i>c</i>][2]benzopyran-1,6-dione and Furo[3,2-<i>c</i>]pyran-4-one Derivatives from the Fungus <i>Phellinus </i><i>i</i><i>gniarius</i>
Journal of Natural Products 2004.0
Farinosones A−C, Neurotrophic Alkaloidal Metabolites from the Entomogenous Deuteromycete <i>Paecilomyces </i><i>f</i><i>arinosus</i>
Journal of Natural Products 2004.0
Farinosones A−C, Neurotrophic Alkaloidal Metabolites from the Entomogenous Deuteromycete <i>Paecilomyces </i><i>f</i><i>arinosus</i>
Journal of Natural Products 2004.0
Asperorydines A–M: Prenylated Tryptophan-Derived Alkaloids with Neurotrophic Effects from <i>Aspergillus oryzae</i>
The Journal of Organic Chemistry 2018.0