Pokepola ester (1), a phosphate diester of mixed biogenetic origin was isolated from a Maui sponge, Spongia oceania. It showed mild anti HIV activity. Phosphate esters are essential elements of nucleotides, which are primary metabolites. They have only rarely been encountered as building blocks of secondary metabolites. Recent examples of phosphate esters as moieties of marine natural products have been the sponge-derived calyculins3 and some polyhydroxysterols from a sea star.4 We now report isolation and structural elucidation of another example of a phosphorus-containing marine natural product. Pokepola ester (1) is a diester of phosphoric acid; the alcohols are 5-methylhexanol and homoserine. The amine of homoserine, in turn, forms an amide with a C12 carboxylic acid, which terminates in a β-substituted furan and appears to be a truncated sesquiterpene.