New antitumor antibiotics, duocarmycins B1 and B2.

The Journal of Antibiotics
1989.0

Abstract

In the course of our screening program for new antitumor antibiotics, we have previously reported on new antibiotics, duocarmycins A(1), Q (2) and C2 (3). Medium modification has produced two new antitumor antibiotics duocarmycins B₁ (4) and B₂ (5) in the fermentation broth of Streptomyces sp. DO-89. In this paper, the production, isolation, physico-chemical properties and biological properties of duocarmycins B₁ (4) and B₂ (5) are reported.

DOI： 10.7164/antibiotics.42.1299

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