<jats:title>Abstract</jats:title><jats:p>Nineteen individual hexalobines (diprenyl‐substituted indoles) were isolated from petroleum ether and dichloromethane extracts of the stem bark of <jats:italic>Hexalobus crispiflorus</jats:italic> and <jats:italic>H. monopetalus</jats:italic>, respectively. The structures were established by spectroscopic methods. The absolute configurations result from chiroptical measurements and from chemical interconversions. Various hexalobines exhibit significant antifungal activity.