Studies on antibiotics from the genus Bacillus. IX. Isolation of brevistin, a new peptide antibiotic.

The Journal of Antibiotics
1976.0

Abstract

A new peptide antibiotic, brevistin, was isolated from the culture broth of Bacillus brevis 342-14. Brevistin is an acylpeptide with an approximate empirical formula of C63H91N15O18 containing aspartic acid, threonine, glycine, valine, isoleucine, phenylalanine, tryptophan and 2,4-diaminobutyric acid. The antibiotic is soluble in acid and alkaline water. Its hydrochloride is soluble in methanol. Brevistin is active against Ggam-positive bacteria in vitro and in vivo, and is of low toxicity to mice.

DOI： 10.7164/ANTIBIOTICS.29.375

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