Studies on the differentiation inducers of myeloid leukemic cells. III. Spicamycin, a new inducer of differentiation of HL-60 human promyelocytic leukemia cells.

The Journal of Antibiotics
1983.0

Abstract

In the course of our screening program for inducers of differentiation of myeloid leukemic cells,1,2) we have recently isolated an active substance from the culture broth of a streptomycete. This antibiotic "spicamycin" is a potent inducer of differentiation of human promyelocytic leukemia cells (HL-60).3)

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