<jats:p>The alkaloids evolitrine, acronycidine, melicopine, melicopidine, normelicopine, normelicopidine, acronycine, noracronycine, 12-desmethylacronycine, (+)-cis-1,2-dihydroxy-1,2-dihydroacronycine, and (-)-trans-1,2-dihydroxy-1,2-dihydroacronycine were isolated from Medicosma subsessilis bark, together with the new 1-oxo-2-hydroxy-1,2-dihydro-12-desmethylnoracronycine. The structure of the latter compound was elucidated on the basis of spectral data and partial synthesis.