Hamacanthins A and B, New Antifungal Bis Indole Alkaloids from the Deep-Water Marine Sponge, Hamacantha Sp.

Journal of Natural Products
1994.0

Abstract

Hamacanthin A [1] and hamacanthin B [2] are two bioactive dihydropyrazinonediylbis(indole) alkaloids isolated from a new species of deep-water marine sponge, Hamacantha sp. The hamacanthins are growth inhibitors of Candida albicans and Cryptococcus neoformans. Isolation and structure elucidation of 1 and 2 by nmr spectroscopy are described.

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