Carquinostatin B, a New Neuronal Cell-protecting Substance Produced byStreptomyces exfoliatus

Bioscience, Biotechnology, and Biochemistry
1997.0

Abstract

Brain ischemia injury is elicited by the excitotoxicity of L-glutamate. Carquinostatin B was isolated from Streptomyces exfoliatus 2419-SVT2 as a potent neuroprotective substance which protests neuronal hybridoma N18-RE-105 cells from L-glutamate toxicity. The structure of carquinostatin B was established principally by NMR studies to be a carbazole derivative with an ortho quinone function.

DOI： 10.1271/BBB.61.1768

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