Callyspongenols A−C, New Cytotoxic C22-Polyacetylenic Alcohols from a Red Sea Sponge, Callyspongia Species

Journal of Natural Products
2003.0

Abstract

Investigation of the organic extract of a Red Sea sponge, Callyspongia sp., resulted in isolation and identification of three new C(22)-polyacetylenic alcohols, callyspongenols A-C (1-3), together with dehydroisophonochalynol (4). The structures of 1-3 were determined by 1D and 2D NMR studies and mass spectral determinations. Compounds 1-4 showed moderate cytotoxicity against P388 and HeLa cells.

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