Bacilsubteramide A, a new indole alkaloid, from the deep-sea-derived Bacillus subterraneus 11593

Abstract

From the deep-sea-derived bacterium Bacillus subterraneus 11593, a new indole alkaloid (1) was isolated along with three known compounds (2-4). By detailed analysis of its NMR spectroscopic data, and further by the theoretical ECD calculations, the absolute configuration of the new compound was determined to be (R)N-[2-(3-hydroxy-2-oxoindolin-3-yl) ethyl] acetamide, and named bacilsubteramide A. All four isolates were tested for anti-allergic bioactivities; however, none exhibited positive effect (IC50 > 0.2 mM). Noteworthily, it is the first report on secondary metabolites from the bacterium B. subterraneus.[GRAPHICS].