Diterpene and flavonoid constituents of the newly identified Australian species Olearia fulgens

Phytochemistry Letters
2020.0

Abstract

The phytochemistry and antimicrobial activity of the newly identified Australian plant Olearia fulgens A.R.Beanwas examined. Antimicrobial TLC bioautography-guided isolation followed by NMR spectroscopy was used toidentify the known compounds 8-O-β-D-xylopyranosyl-ent-8β-hydroxylabdan-15-oic acid (1) and pinocembrin(7), and new compounds 8-O-β-D-xylopyranosyl-ent-labdan-8β,15-diol (2) and ent-15-hydroxyclerod-3-en-17-oicacid (4a). Compounds without apparent activity in TLC bioautography included the previously undescribed entclerod-3-en-15,17-dioic acid (3a) and ent-cleroda-3,13-dien-15,17-dioic acid (5a), as well as known ent-8β-hydroxylabdan-15-oic acid (6) and penduletin (8). This is the first phytochemical and antibacterial study on thisspecies of Olearia, showing it to be an abundant source of ent-labdanes and ent-clerodanes.

Knowledge Graph

Similar Paper