New 24-Membered Macrolides SPA-6952A and B Produced by Streptomyces sp.

The Journal of Antibiotics
2005.0

Abstract

Two new 24-membered macrolides, SPA-6952A and B, were isolated from the fermentation broth of Streptomyces sp. SPA-6952. The structures of the new macrolides were determined by spectral analyses, including 2D NMR techniques. These compounds exhibited cytotoxic activity against human promyelocytic leukemia HL-60 cells.

DOI： 10.1038/JA.2005.52

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