Structures of New Cytotoxic Antibiotics, Piericidins C7 and C8

The Journal of Antibiotics
2007.0

Abstract

Two new cytotoxic antibiotics, piericidins C7 (1) and C8 (2), were isolated from a marine Streptomyces sp. High-resolution FAB-MS established the molecular formulae of 1 and 2 as C28H41NO5 and C29H43NO5, respectively. The planar structures of the piericidins were elucidated by NMR spectral analysis including COSY, HMQC and HMBC. The relative stereochemistry of 2 was determined based on NOESY and coupling constant analyses. 1 and 2 are new members of the piericidin family possessing 11,12-epoxide and 12-butenyl groups.

DOI： 10.1038/JA.2007.23

Knowledge Graph

Similar Paper

Structures of New Cytotoxic Antibiotics, Piericidins C7 and C8
The Journal of Antibiotics 2007.0
Piericidins C5 and C6: new 4-pyridinol compounds produced by Streptomyces sp. and Nocardioides sp.
Bioorganic & Medicinal Chemistry 2003.0
Piericidins C5 and C6: new 4-pyridinol compounds produced by Streptomyces sp. and Nocardioides sp.
Bioorganic & Medicinal Chemistry 2003.0
New Piericidin Antibiotics, 7-Demethylpiericidin A1 and 7-Demethyl-3'-rhamnopiericidin A1.
The Journal of Antibiotics 1996.0
New piericidin glucosides, glucopiericidins A and B.
The Journal of Antibiotics 1987.0
Isolation and structure determination of a novel phosphatidylinositol turnover inhibitor, piericidin B1 N-oxide.
The Journal of Antibiotics 1991.0
Chemical structures of new piericidins produced by Streptomyces pactum.
Agricultural and Biological Chemistry 1977.0
Novel cytocidal antibiotics, glucopiericidinols A1 and A2 Taxonomy, fermentation, isolation, structure elucidation and biological characteristics.
The Journal of Antibiotics 1989.0
Isolation and structure determination of novel phosphatidylinositol turnover inhibitors, piericidin B5 and B5 N-oxide, from Streptomyces sp.
The Journal of Antibiotics 1993.0
Glucopiericidin C: a cytotoxic piericidin glucoside antibiotic produced by a marine Streptomyces isolate
The Journal of Antibiotics 2011.0