From the stem bark of a Zanthoxylum species collected on Grand Cayman Island 12 benzophenanthridine alkaloids have been isolated of which five are new. The novel alkaloids have been identified on the basis of spectral analysis as decarine acetate, 6-carboxymethyldihydrochelerythrine, 6-(4-methyl-2-oxopentanyl)dihydrochelerythrine; chelelactam, 6-[3′-(2-oxopyrrolidinyl)]-dihydrochelerythrine and caymandimerine, 2,2-di[6′-(dihydrochelerythryl)]-acetaldehyde. © 1987.