Constituents of Domestic Citrus Plants. Part XXVI. Studies on the Constituents of Yalaha. Structures of a New Acridone Alkaloid and Two New Coumarins.

Chemical and Pharmaceutical Bulletin
1996.0

Abstract

We have reported the isolation and structure elucidation of new acridone coumarin dimers, called neoacrimarines-A (1), -B (2),2) -E (3),3) acrimarines-I (4), -J (5),4) -N (6), and dioxinoacrimarine-A (7)^3 from the root of Yalaha [several hybrid seedlings resulting from a cross of Duncan grapefruit (Citrus paradisi MACF.) × Dancy tangerine (C. tangerina HORT. ex TANAKA). On continuing our phytochemical studies of this plant, the acetone extract of the root of Yalaha was treated as shown in Fig. 1, and a new acridone alkaloid, 1,3,5-trihydroxy-10-methylacridone (8), and two new coumarins, trans-clausarinol (9) and khelmarin-D (11) were isolated. Together with these new compounds, thirty-eight monomeric coumarins, one dimeric coumarin, eighteen simple acridone alkaloids, one acridone-lignan, seven acridone-coumarin dimers, two flavonoids, and three aromatic compounds were also isolated and characterized. Here, we describe the structure of these new compounds and full details of the isolation and characterization of known compounds.

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