Bruceanols G and H, Cytotoxic Quassinoids from Brucea antidysenterica

Journal of Natural Products
1995.0

Abstract

Two new quassinoids, bruceanols G [1] and H [4], were isolated from Brucea antidysenterica, and their structures were elucidated by spectral evidence and chemical transformation. Bruceanol G exhibited significant cytotoxicity against the COLO-205 and KB neoplastic cell lines with ED50 values of 0.44 and 0.55 microM, respectively.

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