Chemical investigation of the sponge Leucetta chagosensis collected in Chuuk State, Federated States of Micronesia, has led to the isolation of two new alkaloids, 2-deoxy-2-aminokealiiquinone (3) and naamine C (5), along with the known alkaloid, pyronaamidine (1). The structures of 3 and 5 were assigned by spectroscopic and chemical methods. A family of imidazole alkaloids has been isolated from calcareous sponges of the genera Leucetta (order Clathrinida, family Leucettidae) and Clathrina (order Clathrinida, family Clathrinidae) and nudibranchs of the genus Notodoris (family Aegiridae). The Notodoris nudibranchs are known to feed on calcareous sponges of these two genera. Some of these alkaloids show antimicrobial activity, and pyronaamidine (1) is cytotoxic. Several of these alkaloids have been isolated as zinc complexes. As part of our ongoing study of marine organisms, we examined extracts of the sponge Leucetta chagosensis collected in Chuuk State, Federated States of Micronesia. In this paper, we report the isolation and structural elucidation of two new analogues of members of this imidazole alkaloid family.