Six new <i>chiro</i>-inositol derivatives (<b>1</b>-<b>6</b>) were isolated from the leaves of <i>Chisocheton paniculatus</i> collected in Vietnam. Their chemical structures were elucidated by 1D and 2D NMR and HRESIMS analyses. All isolated compounds were evaluated for their inhibitory activity against lipopolysaccharide-induced nitric oxide (NO) production in the RAW 264.7 macrophage cell line. Compound <b>4</b> exhibited potent inhibitory activity for NO production with an IC<sub>50</sub> value of 7.1 μM.