<jats:p> The chemical compositions of the essential oils of the fresh and dried leaves of Ipomea pes-caprae from Mauritius were studied for the first time by gas chromatography-mass spectrometry and 70 compounds were identified. The major components were found to be 8-cedren-13-ol (13.0%), (E)-nerolidol (7.0%), guaiol (6.2%), α-cadinol (6.2%) and limonene (6.1%) in fresh leaves and β-caryophyllene (36.6%), α-copaene (8.0%), germacrene D (7.3%), phytol (5.8%), δ-cadinene (5.7%), and α-humulene (5.4%) in the dried leaf samples. The relationship between the anti-hemorrhoidal activity of Ipomea pes-caprae, one of its traditional uses in Mauritius, and the chemical composition of the essential oil samples is also discussed.