<jats:title>Abstract</jats:title><jats:p>Terpeptin A (1) and B (2), two new members of the indolic enamides, along with three known compounds (3–5) were identified from a strain of <jats:italic>Aspergillus</jats:italic> sp. (w‐6), an endophytic fungus associated with <jats:italic>Acanthus ilicifolius</jats:italic>. The complete <jats:sup>1</jats:sup>H and <jats:sup>13</jats:sup>C NMR assignments for these compounds were carried out using <jats:sup>1</jats:sup>H, <jats:sup>13</jats:sup>C, DEPT, COSY, HMQC, and HMBC NMR experiments. Terpeptin A and B exhibited modest cytotoxicity against A‐549 cell line. Copyright © 2008 John Wiley & Sons, Ltd.