Recently, we have described the discovery of cochinmicins I (1), II (2) and III (3) (Fig. 1) as endothelin antagonists from the fermentation of a Microbispora sp., ATCC 551401 2). Subsequently, in working with a directly scaled up fermentation, we found two additional components, IV (4) and V (5), in sufficient amounts for characterization. In this paper, we will present the isolation as well as physico-chemical and biochemical characterization of these two new metabolites.