Biosynthesis of the Bis-Prenylated Alkaloids Muscoride A and B

ACS Chemical Biology
2019.0

Abstract

Prenylation is a common step in the biosynthesis of many natural products and plays an important role in increasing their structural diversity and enhancing biological activity. Muscoride A is a linear peptide alkaloid that contain two contiguous oxazoles and unusual prenyl groups that protect the amino- and carboxy-termini. Here we identified the 12.7 kb muscoride (

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