Structural elucidation of talopeptin (MK-I), a novel metallo proteinase inhibitor produced by streptomyces mozunensis MK-23

Tetrahedron Letters
1982.0

Abstract

The structure of talopeptin (MK-I), a novel metallo proteinase inhibitor produced by Streptomyces mozunensis MK-23 was elucidated to be 6-deoxy-e-Ltalopyranosyloxyphospho-L-leucyl-L-tryptophan.As reported in the previous papers [1,2], a novel proteinase inhibitor talopeptin (MK-I), which shows a specific inhibitory activity against metallo proteinases, was isolated from the culture filtrate of Streptomyces mozunensis MK-23. It was also reported that talopeptin is composed of 6-deoxyaldohexose, phosphoric acid, leucine and tryptophan. In this paper, structural elucidation of talopeptin is reported.

Knowledge Graph

Similar Paper

Structural elucidation of talopeptin (MK-I), a novel metallo proteinase inhibitor produced by streptomyces mozunensis MK-23
Tetrahedron Letters 1982.0
Leupeptazin, a highly modified tripeptide isolated from cultures of a Streptomyces sp. inhibits cathepsin K
Bioorganic & Medicinal Chemistry Letters 2017.0
Leupeptazin, a highly modified tripeptide isolated from cultures of a Streptomyces sp. inhibits cathepsin K
Bioorganic & Medicinal Chemistry Letters 2017.0
Tyropeptins A and B, New Proteasome Inhibitors Produced by Kitasatospora sp. MK993-dF2. I. Taxonomy, Isolation, Physico-chemical Properties and Biological Activities.
The Journal of Antibiotics 2001.0
6‐Deoxy‐α‐<scp>L</scp>‐talopyranosides from <i>Streptomyces</i> sp.
European Journal of Organic Chemistry 2006.0
Isolation of Propioxatin A from<i>Actinosynnema</i>sp. SI-23 during a Screening for<i>Serratia piscatorum</i>Metalloproteinase Inhibitors
Bioscience, Biotechnology, and Biochemistry 1997.0
Sulphostin, a Potent Inhibitor for Dipeptidyl Peptidase IV from Streptomyces sp. MK251-43F3.
The Journal of Antibiotics 2001.0
Propeptin, a New Inhibitor of Prolyl Endopeptidase Produced by Microbispora. I. Fermentation, Isolation and Biological Properties.
The Journal of Antibiotics 1997.0
A Novel Proteinase Inhibitor, Tyrostatin, Inhibiting Some Pepstatin-insensitive Carboxyl Proteinases
Agricultural and Biological Chemistry 1989.0
Probestin, a new inhibitor of aminopeptidase M, produced by Streptomyces azureus MH663-2F6. II. Structure determination of probestin.
The Journal of Antibiotics 1990.0