The investigation of 27 South African Helichrysum species gave in addition to known compounds, 21 new acylphloroglucinol derivatives, five flavanoids, an unusual pyrone derivative, five diterpenes, a bicyclogermacrene and three cadmene derivatives, three guaianohdes, a xanthanohde, a dimeric sesquiterpene factone, an aftphatic factone and seven glycerol angelate derivatives. The structures were elucidated by high field NMR techniques The chemotaxonomic aspects are discussed in connection with previous investigations