A new neo-clerodane diterpenoid, ajugorientin, has been isolated from Ajuga orientalis. The previously known neo-clerodanes ajugapitin and 14,15-dihydro-15-hydroxyajugapitin have been found in the acetone extract of A. australis. The structure of ajugorientin, (11 S, 13R, 16S)-6e, 19-diacetoxy- 1 fl-(E)-2'-methyl-2'-butenoyloxy-4ct, 18; 11,16; 15,16-triepoxy-neo-clerodan-3fl-ol, was elucidated by spectroscopic means and by comparison with closely related compounds. © 1997 Elsevier Science Ltd. All rights reserved