Nine Bisbenzylisoquinoline Alkaloids from Thalictrum cultratum

Journal of Natural Products
1987.0

Abstract

Thalictrum cultratum collected in northern Pakistan has yielded, besides several known alkaloids, the two norbisbenzylisoquinolines (+)-2'-noroxyacanthine [1] and (+)-2'-northaliphylline [2], the diphenolic imine (+)-cultithalminine [3], and the six N-oxides (+)-neothalibrine-2'-α-N-oxide [7], (-)-thalrugosaminine-2-α-N-oxide [8], (-)-thaligosine-2-α-N-oxide [9], (+)-thaliphylline-2'-β-N-oxide [10], (+)-thalidasine-2-α-N-oxide [11], and (-)-5-hydroxythalidasine-2-α-N-oxide [12]. We have found nine new bisbenzylisoquinolines in our continuing study of Thalictrum cultratum Wall. (Ranunculaceae) that had been collected in northern Pakistan. All of these alkaloids are structurally related to those previously reported in the plant (1,2). Of the nine alkaloids, two were nor bases, one was an imine, while the remaining six were N-oxides.

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