Five new tetralones, daldiniones A-E (<b>1</b>-<b>5</b>), three new chromones, 7-hydroxy-5-methoxy-2,3-dimethylchromone (<b>9</b>), 5-methoxy-2-propylchromone (<b>10</b>), and 7-ethyl-8-hydroxy-6-methoxy-2,3-dimethylchromone (<b>11</b>), and two new lactones, helicascolides D and E (<b>16</b> and <b>17</b>), together with nine known metabolites (<b>6</b>-<b>8</b>, <b>12</b>-<b>15</b>, and <b>18</b>-<b>19</b>) were isolated from the mangrove-derived fungus <i>Daldinia eschscholtzii</i> HJ004. The structures and absolute configurations of the new compounds were determined by analyzing MS and NMR data and utilizing GIAO based <sup>13</sup>C NMR chemical shift calculations and quantum chemical electronic circular dichroism (ECD) calculations. Compounds <b>9</b>, <b>13</b>, and <b>18</b> showed inhibitory activities against α-glucosidase with IC<sub>50</sub> values of 13, 15, and 16 μM, respectively.