4'-N-Methyl-5'-hydroxystaurosporine and 5'-Hydroxystaurosporine, New Indolocarbazole Alkaloids from a Marine Micromonospora sp. Strain.

The Journal of Antibiotics
2000.0

Abstract

Two new indolocarbazole alkaloids, 4'-N-methyl-5'-hydroxystaurosporine (2) and 5'-hydroxystaurosporine (3), were isolated together with the known staurosporine (1) from the culture broth of a marine Micromonospora sp. (strain L-31-CLCO-002). The fermentation, structural data and cytotoxic activities of these compounds against various tumor cell lines are given.

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