Both enantiomers of keramaphidin B (1) were separated by using chiral HPLC, of which one may be a plausible biogenetic precursor of ircinals A (4) and B (5) and manzamines A (2) and B (3), while the other may be associated with antipodes of manzamine alkaloids such as ircinols A (6) and B (7). Isolation and structure elucidation of a new manzamine congener, manzamine L (8), and absolute configurations at C-1 of 8 and manzamines D (10) and H (9) deduced from the Cotton effects are also described.