Isolation of 11,12-seco-Rifamycin W Derivatives Reveals a Cleavage Pattern of the Rifamycin Ansa Chain

Organic Letters
2019.0

Abstract

This study reported the isolation and characterization of 11 rifamycin congeners including six new ones (1-6) from the agar fermentation extract of Amycolatopsis mediterranei S699. Compounds 1 and 2 are rifamycin glycosides named as rifamycinosides A and B, respectively. Their polyketide skeleton represents a novel cleavage pattern of the rifamycin ansa chain. Compounds 6 and 8 showed potential T3SS inhibitory activity, and 6 induced G2/M phase arrest and caused DNA damage in HCT116 cells.

DOI： 10.1021/ACS.ORGLETT.8B03792

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