Four sesquiterpene glycosides were isolated from the leaves of Eriobotrya japonica. The structures were established as 1-4 through spectral studies (fabms and nmr) and chemical methods. The leaves of Eriobotrya japonica Lindl. (Rosaceae), a small tree commonly known as loquat, are documented for use as a folk medicine for the treatment of various skin diseases (1) and diabetes mellitus (2). Winter et al. (3) found that the alcoholic extract of the leaves exhibited an anti-inflammatory effect on carrageenan-induced foot edema in rats. More recently Shimizu et al. (1) reported the isolation of some known triterpenes from the Et₂O-soluble fraction of an EtOH extract of the leaves and among these, maslinic acid was found to have strong anti-inflammatory activity. In a recent communication Noreen et al. (4) have reported a significant hypoglycemic effect of the alcoholic extract in rabbits. In view of the pharmaceutical interest of this species, we have been investigating the constituents of the CHCl₃, MeOH, and H₂O extracts, isolating a new polyhydroxylated terpenoid together with other known triterpenes from the CHCl₃ extract (5). The present paper deals with the further isolation and characterization of four new sesquiterpene glycosides 1-4 from the MeOH extract; this is the first report of the occurrence of glycosides of nerolidol in nature.