New Oxoaporphine Alkaloids from Hernandia nymphaeifolia

Journal of Natural Products
1996.0

Abstract

Through continuing studies on the constituents of the stem bark of the Formosan plant, Hernandia nymphaeifolia Kubitzki (Hernandiaceae), three new oxoaporphine alkaloids, oxohernagine (1), oxohernangerine (2), and hernanymphine (3), were isolated from the tertiary basic parts of the CHCl3-soluble fraction. Earlier papers1-11 have shown both aporphine alkaloids and lignans as characteristic constituents of Hernandia nymphaeifolia (Presl) Kubitzki (Hernandia peltata Meissn.) (Hernandiaceae),12-14 and Formosan species were often mislabeled as Hernandia ovigera L. or Hernandia sonora L. in Taiwan and Japan for many years. In our chemical investigations of Formosan species collected on Green Island, we were able to isolate six new aporphine alkaloids, 7-formyldehydroovigerine, 7-formyldehydronornantenine, dehydrohernandaline, sonodione, demethylsonodione, and norsonodione, and 10 known compounds from the stem bark.8,9 Further examination of the tertiary basic fraction of the stem bark of this plant has now resulted in the characterization of three new oxoaporphines, namely oxohernagine (1), oxohernangerine (2), and hernanymphine (3), as additional constituents.

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