Umbrosine — A new alkaloid from Aconitum umbrosum

Chemistry of Natural Compounds
1976.0

Abstract

From the roots of the previously unstudied species Aconitum umbrosum collected in the flowering period in the environs of Utkura (Sikhot6-Alin' range) we have isolated lycaconitine, anthranoyllycaconitine, ajacine, and a new base with the composition C24H39NO6, mol. wt. 437.2738, mp 150-151°C (hexane), which we have called umbrosine (I). According to its NMR spectrum (CDC13, δ scale), the alkaloid contains a methyl group (1.05 ppm, 3H, triplet) and three methoxy groups (3.33, 3.28, and 3.26 ppm, 3H each). Its composition and spectral characteristics permit the conclusion that umbrosine is based on a lycoctonine skeleton, and the subsequent chemical reactions of (I) confirmed this hypothesis.

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