Aerial parts of Ipomoea cairica L. Sweet (Convolvulaceae), a folk medicinal plant found in Brazil and elsewhere, were collected at Governador Valadares, Minas Gerais, Brazil, in May, 2000, and a voucher specimen (No. BHCB 16525) was deposited at Herbarium of Natural History Museum of Universidade Federal de Minas Gerais. The plant material was dried, reduced to powder (3.297 g), and macerated with ethanol for seven days. The crude extract yielded 250 g after evaporation to dryness. The ethanolic extract (100 g) was partitioned in a triphasic mixture of hexane–acetonitrile–CHCl3–H2O (2:3.4:1:1). The aqueous layer yielded 57 g and part (37 g) was fractionated by silica gel CC using a gradient starting with CH2Cl2–MeOH–H2O (80:20:1) with increasing polarity up to (10:90:12). The fraction eluted with CH2Cl2–MeOH–H2O (45:55:8) was chromatographed on modified silica gel 60A (phosphate buffer (NaH2PO4/H3PO4)) [1] eluted with hexane:EtOAc (up to 100% EtOAc) and EtOAc:MeOH (up to 40% MeOH) to obtain 1 (9 mg) and 2 (36 mg) in fractions eluted with EtOAc–MeOH (95:5). Compounds 1 and 2 have been isolated from I. cairica for the first time.