<jats:p>Corazonin, a new cardioaccelerating peptide, has been isolated from the corpora cardiaca of the American cockroach, <jats:italic>Periplaneta americana</jats:italic>, and its structure determined to be Glp‐Thr‐Phe‐Gln‐Tyr‐Ser‐Arg‐Gly‐Trp‐Thr‐Asn‐amide. The peptide stimulated heart beat at concentrations as low as 0.2 nM, which makes it the most potent insect cardioactive neuropeptide.