Three new derivatives, anthranosides A-C (1-3), were discovered from a marine sponge-derived actinomycete Streptomyces sp. CMN-62. Their structures including absolute configurations were elucidated using MS and NMR spectroscopic data, X-ray single-crystal diffraction analysis, and chemical synthesis. Compounds 1 and 2 are epimers composed by linking the anthranilate unit to the fructofuranose moiety via a carbon-nitrogen bond, while 3 possessed a unique indole-containing scaffold. All compounds were tested for cytotoxicity, anti-influenza H