Nine xanthone aglycones and one xanthone glycoside have been identified in Schultesia lisianthoides. Seven of the aglycones have been isolated and their structures elucidated by UV, mass and NMR spectroscopy; three xanthones were identified on-line by HPLC-UV and HPLC-mass spectrometry. 5-Hydroxy-1,2,3-trimethoxyxanthone is a new natural product. The other constituents have already been encountered in different Gentianaceae species.