Dioscoretine: The Hypoglycemic Principle ofDioscorea dumetorum

Planta Medica
1990.0

Abstract

The tuber of Dioscorea dumetorum (Kunth) Fax (Dioscoreaceae) is used in traditional medicine in carefully regulated doses for the management of diabetes mellitus (1). Crude extracts of D. dumetorum have been shown to possess a hypoglycemic effect in fasted normal rats and rabbits and also checked hyperglycemia due to the effects of alloxan (2). We had previously reported the isolation and structure elucidation of dihydrodioscorine as well as the new alkaloid dumetorine from the tubers of D. dumetorum (3). From the previous investigations, the aqueous fraction of the alcoholic extract was associated with the hypoglycemic activity of the plant. In the present study, we have isolated the hypoglycemic agent of this plant by bioassay-guided fractionation of the methanolic extract. The stems of Berchemia racemosa Sieb. et Zucc. (Rhamnaceae) have been used in Japan as a folk medicine for gall stones and stomach-ache. From the stems of B. racemosa, some compounds such as eriodictyol, kaempferol (1), and angelicoidenol glucosides (2) were isolated. This paper deals with the isolation of compounds 1 and 2.

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