New atisine-type alkaloids, spiramines A, B, C, and D were isolated from Spiraea japonica and their structures were elucidated by chemical and spectroscopic means. The plant of Spiraea japonica var. acuminata was used as the folk medicine (Chinese name chui huo tong) in China. From the dried roots of this plant collected in Kunming, Yunnan province of China, we isolated fifteen new atisine-type alkaloids and a new atisane-type diterpene. Here we report the structures of main alkaloids, spiramines A (1), B (2), C (3), and D (4).