Two new triterpenes of the taraxasterol skeleton are isolated for the first time form Pergularia tomentosa L. of Algerian origin. The new compounds were named pergularine A and pergularine B. In addition, eight known compounds were isolated from the plant including oleic acid, (9Z,12Z)-octadecadienoic acid, α-amyrin, 3-acetyltaraxasterol, 3-taraxasterol, 16α-hydroxytaraxasterol-3-acetate, 3-epi-micromeric acid, and (9Z,12Z)-octadecadienoic acid glucoside. All known compounds are isolated for the first time from P. tomentosa L.