MICROBIAL CONVERSION OF ANTHRACYCLINE ANTIBIOTICS I. MICROBIAL CONVERSION OF ACLACINOMYCIN BTO ACLACINOMYCIN A

The Journal of Antibiotics
1983.0

Abstract

Streptomyces galilaeus OBB-111 and its blocked mutant were found to convert aclacinomycin B and related anthracycline glycosides of the B type to the corresponding A-type glycosides. Only the cell fraction of cultures of S. galilaeus OBB-111 was capable of catalyzing the reaction. The activity was associated with growth but disappeared before the start of rapid production of aclacinomycins A and B.

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