Host-dependent heterologous expression of berninamycin gene cluster leads to linear thiopeptide antibiotics

Organic & Biomolecular Chemistry
2021.0

Abstract

<jats:p>Linearized berninamycin analogues were generated by heterologous expression of the <jats:italic>ber</jats:italic> biosynthetic gene cluster from deep-sea derived <jats:italic>Streptomyces</jats:italic> sp. SCSIO 11878 in <jats:italic>S. albus</jats:italic>, but neither in <jats:italic>S. lividans</jats:italic> nor in <jats:italic>S. coelicolor</jats:italic>.

Knowledge Graph

Similar Paper