Nine new ent-kauranoids, sculponins D-L (1-9), and 14 known diterpenoids (10-23) were isolated from the aerial parts of Isodon sculponeatus. The structures of the new diterpenoids were determined by detailed interpretation of their 1D and 2D NMR spectra and HRESIMS. The isolated compounds were evaluated for their cytotoxic activities against a small panel of human cancer cell lines.