The complete stereostructure of hazuntamine, a new bisindole alkaloid from Hazunta modesta var. methuenii subvar. methuenii, has been determined mainly by the use of different spectroscopic means. Plants of the genus Hazunta (Apocynaceae) are native to different regions of Madagascar. In a continuation of our studies on alkaloids of different Hazunta plants, we have now examined the root bark of Hazunta modesta var. methuenii subvar. methuenii growing in a region different from where a previously investigated species of the same botanical variety was collected. Direct crystallization as well as repeated chromatography of the CH₂Cl₂ extract of the air-dried root bark afforded two newly isolated alkaloids, namely, dregamin-3α-ol and hazuntamine, besides the previously isolated known compounds silicine, ibogamine, 19',20'-dihydrotabernamine, methuenine, tabernaemontanine, dregamine, 6-oxosilicine, dihydroellipticine, and 16-epimethuenine. We describe here the identification of dregamin-3α-ol and the structure elucidation of hazuntamine which was found to be a new bisindole alkaloid.