Isolation and identification of amides from Piper callosum. Synthesis of pipercallosine and pipercallosidine

Journal of the Chemical Society, Perkin Transactions 1
1982.0

Abstract

Extraction of the roots of the shrub Piper callosum with cyclohexane afforded piperovatine (1 ) [N-isobutyl-6-(pmethoxyphenyl)sorbamide] and two new amides, the isobutylamides of (2€,4€) -9- (3,4-methylenedioxyphenyl) nona-2,4-dienoic acid and (E) -7- (3,4-methylenedioxyphenyl) hept-2-enoic acid, named pipercallosine (3) and pipercallosidine (14), respectively. The structures of the two new amides have been confirmed by synthesis.

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