A Cytotoxic Sesquiterpene Caffeate from the Liverwort Bazzania novae-zelandiae

Journal of Natural Products
2000.0

Abstract

Extracts of the liverwort Bazzania novae-zelandiae were cytotoxic, with selective activity against human tumor cell lines. Bioactivity-directed isolation work showed that the new compound naviculyl caffeate (1) was the main cytotoxin. This structure was confirmed by synthesis from the co-occurring sesquiterpene naviculol (2).

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