Two new steroidal alkaloids, solanopubamides A and B, were isolated from the aerial parts of Solanum pubescens. Their structures were elucidated as 3β-formylamino-5α,22αH,25βH-solanidan-23β-ol (solanopubamine A) and 3β-acetylamino-5α,22αH,25βH-solaiiidan-23β-ol (solanopunamide B) by spectral and chemical methods. © 1986.