Benastatins A and B, new inhibitors of glutathione S-transferase, produced by Streptomyces sp. MI384-DF12. I. Taxonomy, production, isolation, physico-chemical properties and biological activities.

The Journal of Antibiotics
1992.0

Abstract

Benastatins have been isolated as part of a program designed to find microorganism-produced inhibitors of glutathione S-transferase from Streptomyces sp. MI384-DF12. They were purified by chromatography of reversed-phase silica gel, silica gel and Capcell Pak C18 (HPLC) followed by solvent extraction and then isolated as yellow powders. Benastatins A and B have the molecular formulae, C30H28O7 and C30H30O7, respectively. They were competitive with 3,4-dichloronitrobenzene as the substrate, and the inhibition constants (Ki) of benastatins A and B were 5.0 x 10(-6) and 3.7 x 10(-6), respectively.

DOI： 10.7164/antibiotics.45.1385

Knowledge Graph

Similar Paper

Benastatins A and B, new inhibitors of glutathione S-transferase, produced by Streptomyces sp. MI384-DF12. I. Taxonomy, production, isolation, physico-chemical properties and biological activities.
The Journal of Antibiotics 1992.0
Cysfluoretin, a new inhibitor of glutathione S-transferase, produced by Streptomyces sp. MI384-DF12.
The Journal of Antibiotics 1993.0
Cysfluoretin, a new inhibitor of glutathione S-transferase, produced by Streptomyces sp. MI384-DF12.
The Journal of Antibiotics 1993.0
Bequinostatins A and B, new inhibitors of glutathione S-transferase, produced by Streptomyces sp. MI384-DF12. Production, isolation, structure determination and biological activities.
The Journal of Antibiotics 1993.0
Benzastatins A, B, C, and D: New Free Radical Scavengers from Streptomyces nitrosporeus 30643. I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Activities.
The Journal of Antibiotics 1996.0
Biosynthesis of benastatin A.
The Journal of Antibiotics 1992.0
Nagstatin, a new inhibitor of N-acetyl-.BETA.-D-glucosaminidase, produced by Streptomyces amakusaensis MG846-fF3. Taxonomy, production, isolation, physico-chemical properties and biological activities.
The Journal of Antibiotics 1992.0
Nagstatin, a new inhibitor of N-acetyl-.BETA.-D-glucosaminidase, produced by Streptomyces amakusaensis MG846-fF3. Taxonomy, production, isolation, physico-chemical properties and biological activities.
The Journal of Antibiotics 1992.0
Induction of Apoptosis and Cell Cycle Arrest in Mouse Colon 26 Cells by Benastatin A
Japanese Journal of Cancer Research 2000.0
Benadrostin, new inhibitor of poly(ADP-ribose) synthetase, produced by actinomycetes. I. Taxonomy, production, isolation, physico-chemical properties and biological activities.
The Journal of Antibiotics 1988.0